27Chemoenzymatic Diazo Synthesis Enabled by Enzymatic Halide Recycling with Vanadium-Dependent Haloperoxidases
26Structural Insights into the Mechanism of a Vanadium-Dependent Bromoperoxidase Enabled by High-Resolution Cryo-EM
Hessefort, L.Z.; Williams, D.R.; Biegasiewicz, K.F.*
ChemRxiv 2024
25Intermolecular Heterocycle Synthesis Enabled by Enzymatic Halide Recycling with Vanadium-Dependent Haloperoxidases
Sharma, M.; Pascoe, C.A.; Jones, S.K.; Davis, K.M.*; Biegasiewicz, K.F.*
ChemRxiv 2024
24N-Halogenation by Vanadium-Dependent Haloperoxidases Enables 1,2,4-Oxadiazole Synthesis
Sharma, M.; Patton, Z.E.; Shoemaker, C.R.; Biegasiewicz, K.F.*
Angew. Chem. Int. Ed. 2024, Accepted.
23A radical development for enzymatic fluorination
Gross, E.J.; Biegasiewicz, K.F.*
Nat. Synth. 2024, https://doi.org/10.1038/s44160-024-00540-6
22Decarboxylative Halogenation of Indoles by Vanadium Haloperoxidases
Harstad, L.J.; Wells, C.E.; Lee, H.J.; Ramos, L.P.T.; Sharma, M.; Pascoe, C.A.; Biegasiewicz, K.F.*
Chem. Commun. 2023, 59, 14289.
Part of the 2023 Emerging Investigators Collection
21Chemoenzymatic Synthesis: Cooperativity Enables Opportunity
Hessefort, L.Z.; Harstad, L.J.; Merker, K.R.; Ramos, L.P.T.; Biegasiewicz, K.F.*
ChemBioChem 2023, 24 (12), 1-17.
20Decarboxylative Bromooxidation of Indoles by a Vanadium Haloperoxidase
Wells, C.E.; Ramos, L.P.T.; Harstad, L.J.; Hessefort, L.Z.; Lee, H.J.; Sharma, M.;
Biegasiewicz, K.F.*
ACS Catal. 2023, 13 (7), 4622.
19A Radical-Relay Approach to Biocatalytic C-N Bond Formation
Tennant, J.J.; Biegasiewicz, K.F.*
Chem Catalysis 2022, 2, 2448.
18Quaternary Charge-Transfer Complex Enables Photoenzymatic Intermolecular Hydroalkylation of Olefins
Page, C.G.; Cooper, S.J.; DeHovitz, J.S.; Oblinsky, D.G.; Biegasiewicz, K.F.; Antropow, A.H.; Armbrust, K.W.; Ellis, J.M.; Harmann, L.G.; Horn, E.J.; Oberg, K.M.; Scholes, G.D.; Hyster, T.K.*
J. Am. Chem. Soc. 2021, 143 (1), 97.
17Organic Chemistry: A Retrosynthetic Approach to a Diverse Field
Ackerman-Biegasiewicz, L.K.G.; Arias-Rotondo, D.M.; Biegasiewicz, K.F.; Elacqua, E.*; Golder, M.R.; Kayser, L.V.; Lamb, J.R.; Le, C.M.; Romero, N.A.; Wilkerson-Hill, S.M.; Williams, D.A.
ACS Cent. Sci. 2020, 6 (11), 1845.
16Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts
Nakano, Y.; Black, M.J.; Meichan, A.J.; Sandoval, B.A.; Chung, M.M.; Biegasiewicz, K.F.; Zhu, T.; Hyster, T.K.*
Angew. Chem. Int. Ed. 2020, 59 (26), 10484.
15Asymmetric Redox-Neutral Radical Cyclization Catalysed by Flavin-Dependent ‘Ene’-Reductases
Black, M.J.; Biegasiewicz, K.F. Meichan, A.J.; Oblinsky, D.G.; Kudisch, B.; Scholes, G.D.; Hyster, T.K.*
Nat. Chem. 2020, 12, 71.
14Photoenzymatic Catalysis Enables Radical‐Mediated Ketone Reduction in Ene‐Reductases
Sandoval, B.A.; Kurtoic, S.I.; Chung, M.M.; Biegasiewicz, K.F.; Hyster, T.K.*
Angew. Chem. Int. Ed. 2019, 58, 8714.
13Photoexcitation of Flavoenzymes Enables a Stereoselective Radical Cyclization
Biegasiewicz, K.F.; Cooper, S.J.; Gao, X.; Oblinsky, D.G.; Kim, J.H.; Garfinkle, S.E.; Joyce, L.A.; Sandoval, B.A.; Scholes, G.D.; Hyster T.K.*
Science 2019, 364, 1166.
12Biocatalytic Hydrogen Atom Transfer: an Invigorating Approach to Free-Radical Reactions
Nakano, Y.; Biegasiewicz, K.F.; Hyster, T.K.*
Curr. Opin. Chem. Biol. 2019, 49, 16-24.
11Catalytic Promiscuity Enabled by Photoredox Catalysis in Nicotinamide-Dependent Oxidoreductases
Biegasiewicz, K.F.; Cooper, S.J.; Emmanuel, M.A.; Miller, D.C.; Hyster, T.K.*
Nat. Chem. 2018, 10, 770.
10Scalable Synthesis of (−)-Rasfonin Enabled by a Convergent Enantioselective α-Hydroxymethylation Strategy
Boeckman Jr., R.K.*; Niziol, J.M.; Biegasiewicz, K.F.
Org. Lett. 2018, 20 (16), 5062.
9Formaldehyde
Concepcion, A.B.; Yamamoto, H.; Boeckman Jr., R.K.; Biegasiewicz, K.F.; Tusch, D.J.
e-EROS Encyc. Reagents Org. Synth. 2018.
8Organocatalyzed Direct Asymmetric α-Hydroxymethylation of Aldehydes
Boeckman, Jr., R.K.*; Tusch, D.J.; Biegasiewicz, K.F.
Org. Synth. 2015, 92, 320.
7(S)-1,1-Diphenylprolinol Trimethylsilyl Ether
Boeckman, Jr., R.K.*; Tusch, D.J.; Biegasiewicz, K.F.
Org. Synth. 2015, 92, 309.
6Organocatalytic Enantioselective α-Hydroxymethylation of Aldehydes: Mechanistic Aspects and Optimization
Boeckman, Jr., R.K.*; Biegasiewicz, K.F.; Tusch, D.J.; Miller, J.R.
J. Org. Chem. 2015, 80 (8), 4030.
5Cubane: 50 Years Later
Biegasiewicz, K.F.; Griffiths, J.R.; Savage, G.P.; Tsanaktsidis, J.; Priefer, R.*
Chem. Rev. 2015, 115 (14), 6719.
4Development of a General Approach to the Synthesis of a Library of Isoflavonoid Derivatives
Biegasiewicz, K.F.; Gordon IV, J.S.; Rodriguez, D.A.; Priefer, R.*
Tetrahedron Lett. 2014, 55, 5210.
3CHAPTER 5. Chemistry and Synthesis of Daidzein and its Methylated Derivatives: Formononetin, Isoformononetin, and Dimethyldaidzein
Carroll, V.M.; St. Denis, J.D.; Biegasiewicz, K.F.; Priefer, R.*
Food Nutr. Compon. Focus 2013, 5 (isoflavones), 61.
2Evaluation of a Chiral Cubane-Based Schiff Base Ligand in Asymmetric Catalysis Reactions
Biegasiewicz, K.F.; Ingalsbe, M.L.; St. Denis, J.D.; Gleason, J.L.; Ho, J.; Coote, M.L.; Savage, G.P.; Priefer, R.*
Beilstein J. Org. Chem. 2012, 8, 1814.
1An Efficient Synthesis of Daidzein, Dimethyldaidzein, and Isoformononetin
Biegasiewicz, K.F.; St. Denis, J.D.; Carroll, V.M.; Priefer, R.*
Tetrahedron Lett. 2010, 51, 4408.